Oct 23, 2018
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Studying Microflora: Bioflavonoids For Better Skin Appearance

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Studying Microflora: Bioflavonoids for better skin appearance. The microflora is an important part of the skin. Sebum and corneocytes as well as sweat create the ideal feeding ground for the tolerated microbes.

Check out New Trends in Cosmetic Technology

The present article describes a new active containing bioflavonoids from Maclura cochinch­inensis. Which was tested for its capability to rebalance the disturbed microflora of oily skin and, in turn, reduce acne blemishes as well as axillary odor.

The Microbial Settlement on the Skin

The Microbial Settlement on the Skin

The skin is our largest organ, with a surface area of roughly 1.​7 square meters. It protects us from the environment, is important for thermore­gulation and is definitely key for our appearance. However, we are not alone in our skin millions of small companions are settling on our skin’s surface: microbes. In total, 100 billion bacteria and fungi use our skin as their habitat. This incredibly large number corresponds to the entirety of our skin cells.

Recent advances in microbiome analysis techniques revealed a much higher bacterial diversity on skin than previously detected by culture-based methods. For example, studies by the authors’ company on acne prone skin have revealed bacteria from six phyla. More than 80 families and no less than 500 different species. One can imagine this is only a fraction of what can be found in normal skin. Furthermore, skin of different ethnicities and of people who live on different continents may harbor even greater microbe diversity.


There are approximately 4,000 naturally occurring plant metabolites called bioflavonoids. These compounds are responsible for the vibrant-color of many fruits, vegetables, and flowers. They can also defend your skin against the damaging effects of stress, pollution, and even age itself.

Bioflavonoids have the ability to neutralize reactive oxygen species by donating one of their electrons. Thus stabilizing the molecule and breaking the oxidative chain. This can result in visible signs of healthy, more vibrant skin.

Three of the better-known bioflavonoids, quercetin, hesperidin, and rutin, have intriguing research indicating their abilities to prevent and reverse wrinkles, reduce the appearance of age spots, and fight spider veins.

Turn Back the Clock on Aging

Turn Back the Clock on Aging

You might think wrinkles are an inevitable part of aging. But by combating wrinkles at the cellular level, not only can you prevent them from occurring.  You can rejuvenate skin that is already showing the signs of old age.
Quercetin, a bioflavonoid found in apples, berries, parsley, onions, grapefruit, and wine, has proven antioxidant and anti-inflammatory properties.

When applied topically. Quercetin has been shown to protect the skin’s natural antioxidants from depletion caused by UVA irradiation. This action helps decrease the oxidative damage caused by exposure to the sun.

But quercetin real anti-aging power comes from its ability to extend the survival and viability of human skin cells. When skin cells stop replicating. Your skin loses elasticity and collagen. Which results in wrinkles. One study showed that when quercetin and rutin (another bioflavonoid) were applied to dying skin cells that had ceased to replicate. The skin cells will rejuvenate and began to reproduce again.

Another interesting property of quercetin is its ability to increase the production of collagen a substance necessary for vibrant skin. This beneficial effect has made it an increasingly popular ingredient in more and more skin care products aimed at combating wrinkles.

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The Secret to Younger-looking Skin

The Secret to Younger-looking Skin

Only a decade or so ago, anti-aging products concentrated primarily on reducing wrinkles. Plumping up the skin to produce a smoother. More youthful appearance. And although combating wrinkles is a necessary step in any anti-aging routine. It’s not the only factor in maintaining younger-looking skin.
Research has demonstrated that there’s another factor that plays a significant role in how old you look: the evenness of your skin tone. The ability to lessen the appearance of age spots and the capacity to provide a lightening effect for sallow. Age-damaged skin is central to achieving this goal. One of the best ways to do that is with the bioflavonoid hesperidin.

Hesperidin has a similar structure to hydroquinone, a compound that has long been considered the professional gold standard for the treatment of age spots and other hyperpigmentation disorders. Like hydroquinone, hesperidin works by limiting the capacity of the skin cells to produce tyrosinase, the enzyme responsible for producing the skin pigment melanin. However, unlike hydroquinone, hesperidin does not come with a list of side effects. In fact, research has demonstrated that hesperidin safely produces a reduction in tyrosinase activity. By interfering with tyrosinase activity, hesperidin is ultimately able to inhibit the development of age spots.

Hesperidin has outstanding potential for cosmetic use. Its vasoprotective and skin-lightening actions work to counteract many of the visible signs of aging.

Rejuvenate From the Inside Out

Wrinkles and age spots aren’t the only visible signs of aging. Spider veins and varicose veins are unsightly. Often embarrassing reminders that we’re not as young as we used to be. Although many people believe that these are inevitable factors in the aging process, research has proven that it is possible to defy these signs of old age.

Spider veins and varicose veins occur as a result of the gradual weakening and deterioration of capillaries. In order to maintain healthy blood circulation. It’s imperative that the arteries and capillaries be kept as clean and strong as possible. Unfortunately, being so small, the capillaries are extremely susceptible to damage from free radical assault, aging, and other factors that can lead to compromised integrity and function. This can lead to rupturing and bleeding that is visible as “broken veins” on the surface of the skin. However, maintaining the health of the circulatory system can prevent this type of damage from occurring.

One of the best ways to maintain the health of your capillaries is with a bioflavonoid found naturally in fruits and vegetables called rutin. Rutin has the capacity to regenerate vitamin C after it neutralizes a free radical, thus helping to restore its antioxidant potential. Because vitamin C plays a critical role in the manufacture of collagen, an important component of capillary walls as well as the sustaining framework of the epidermis, this could have a dramatic impact on the health of your skin.


Has the ability to protect skin from damage caused by advanced glycation end products (AGEs). AGEs accelerate the aging of skin cells, which cause the skin to lose elasticity and collagen. One clinical study found that rutin can effectively modulate the breakdown of collagen caused by AGEs.

Rutin’s ability to provide microvascular protection, improve circulation, and defend against free radical damage makes it an excellent ingredient in any natural skin care formulation for aging skin. Also, because rutin can penetrate the skin, its use in a topical skin care formulation makes it extremely valuable.

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